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Millikin University > Millikin University Blogs > Alumni Blogs > The ups and downs of life as a Ph.D. student > Posts > What I came here to do...
I began my first rotation through Dr. Clark Wells' lab in the second week of October. I have been paired with a fourth year student named Bill and we have been working on polarity. I can break down my project into three main parts that surround one polarity protein in particular: Angiomotin (aka AMOT). AMOT has demonstrated substantial influence in the development of cancer.
1. The Drug Assay
    In this project we are taking various small molecules, developed by IUSM's pharmacology department to target and bind AMOT, and examining their effects on breast cancer cells.
2. Immunofluorescent imaging of breast cancer cells.
    In this project we are using various antibodies to bind and fluoresce AMOT and other key proteins. This allows us to visualize the location of these proteins in the cell which provides additional information about their functions.
3. Peptide Synthesis  
    In this project we are synthesing a peptide with a very specific amino acid sequence with an AMOT binding domain. Peptides are growing to become more widely examined in research as potential drugs that exhibit favorable properties.

I am so excited to be working in the lab! I finally feel like I am doing what I came here to do!
I miss you Millikin,
Millikin University - Decatur, IL
Millikin University - Decatur, IL